Protective effects of Zingiber officinale extract on myocardium and placenta against labetalol-induced histopathological, immune-histochemical, and ultrastructural alterations in pregnant rats
نویسندگان
چکیده
Abstract Background Labetalol is an antihypertensive drug commonly used in obstetrics for both long-term treatment and the acute management of severe maternal hypertension. However, there have not been published articles about effects labetalol on myocardium placenta. This study aimed to estimate histological, immune-histochemical, ultrastructural cardio- placental-toxicity administration effectiveness ginger against this toxicity pregnant rats. was daily administrated orally with or without at a dose 300 mg/kg 200 mg/kg, respectively, during gestation days 6 20. Results In labetalol-administrated group, displayed histological ultrastructure destructive changes significant increase caspase-3 expression. also decreased placental weight compared control caused marked degeneration disorganization their architecture, increased Co-administration after highly ameliorates adverse effect cardiac tissues. Conclusions It concluded that can mitigate induced by into
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ژورنال
عنوان ژورنال: The Journal of Basic and Applied Zoology
سال: 2021
ISSN: ['2090-990X', '2090-9896']
DOI: https://doi.org/10.1186/s41936-021-00238-7